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In these animal models of hypertension, blood pressure is reduced in males by castration [6–9,14,15], but is not increased in females by ovariectomy [16,17].

Thus, sex-associated differences in blood pressure also may be due to changes in testicular hormones.

However, data on the effects of estrogenic preparations on blood pressure are inconsistent, and include reports of blood pressure lowering [30–45], blood pressure elevating [46–51], and blood pressure neutral effects [37,52–54].

Evidence for blood pressure elevating effects of estrogen preparations comes primarily from studies conducted between 1970 and the early 1980s that used conjugated estrogens or contraceptive estrogens (different from natural estradiol) and conventional rather than ambulatory blood pressure measurements.

This suggests that factors in addition to estradiol modulate blood pressure in pregnancy [29] and/or that other hormones or local modulators generated during pregnancy abrogate the blood pressure lowering effects of estradiol during the third trimester of pregnancy.

“NBC has been an amazing partner, it launched the show beautifully,” he said.Estradiol levels increase 50–180-fold during pregnancy [27], and these increases are associated with substantial reductions in blood pressure [28].The timing of maximal decreases in blood pressure and maximal increases in estradiol levels does not coincide completely, however.For example, in several studies, Premarin™ (a mixture of conjugated estrogens isolated from urine of pregnant mares) increased blood pressure [46,50,51], and various synthetic contraceptive estrogens increased the risk of hypertension [55–60].Of five women who developed hypertension after using Premarin (1.25 mg/day) for 3 months to 5 years, four became normotensive from 1 to 7 months after they cessation of therapy [46].

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In the first, second and third trimesters of pregnancy, estradiol levels increase by 8-, 15- and 186-fold [27], respectively.

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